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Genetic susceptibility mechanisms. Most susceptibility loci map to non-coding locations with the genome, are primarily situated in Lively promoters or enhancers, and modify the binding web sites of numerous transcription factors.
Deep, focused future-generation sequencing has discovered that subclonal mutations (i.e., Individuals present in just a portion of tumor cells) may be detected for all driver genes and are linked to immediate condition progression and bad result.eleven–thirteen This is especially appropriate for TP53
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